TD-0212 (TFA)

CAS NO.：1073549-11-7
Empirical Formula: C30H35F4N3O6S
Molecular Weight: 641.68
Update Date: 2026-04-24 14:58:15

What is TD-0212 (TFA)?

Description

TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].

TD-0212 provides the enhanced activity of dual AT1/NEP inhibition with a potentially lower risk of angioedema relative to dual ACE/NEP inhibition[1].

TD-0212 produces blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors in models of renin-dependent and -independent hypertension[1].

References

[1]. McKinnell RM, et al. Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI). ACS Med Chem Lett. 2018 Dec 3;10(1):86-91.

Properties of TD-0212 (TFA)

storage temp.	Store at -20°C
solubility	DMSO: 125 mg/mL (194.80 mM)
form	Solid
color	White to off-white

Safety information for TD-0212 (TFA)

Computed Descriptors for TD-0212 (TFA)

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