TCO-carbonate
Synonym(s):(E)-4-Cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl ester carbonic acid;trans-4-Cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl carbonate;TCO-N-hydroxysuccinimidyl carbonate;TCO-carbonate;TCO-NHS
- CAS NO.：1191901-33-3
- Empirical Formula: C13H17NO5
- Molecular Weight: 267.28
- MDL number: MFCD24386372
- Update Date: 2026-05-11 16:31:51
What is TCO-carbonate?
Description
TCO-NHS Ester is an popular reagent to label amine-containing compound or biomolecule, TCOI enable fast click chemistry with tetrazine.
The Uses of TCO-carbonate
Succinimidyl carbonate/NHS functionalized cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging.
What are the applications of Application
TCO-NHS ester is an amine-reactive building block used to derivatize primary amine-containing molecules with a TCO moiety
Properties of TCO-carbonate
| Melting point: | 90-105°C |
| Boiling point: | 369.1±45.0 °C(Predicted) |
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| color | White to off-white |
| InChI | InChI=1S/C13H17NO5/c15-11-8-9-12(16)14(11)19-13(17)18-10-6-4-2-1-3-5-7-10/h1-2,10H,3-9H2/b2-1+ |
Safety information for TCO-carbonate
Computed Descriptors for TCO-carbonate
| InChIKey | OUGQJOKGFAIFAQ-OWOJBTEDSA-N |
| SMILES | C(ON1C(=O)CCC1=O)(=O)OC1CCCC=CCC1 |t:16| |
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