TASIN-1 hydrochloride
- CAS NO.：1678515-13-3
- Empirical Formula: C18H29ClN2O3S
- Molecular Weight: 388.95
- MDL number: MFCD31697721
- Update Date: 2026-05-11 19:39:08
What is TASIN-1 hydrochloride?
Description
TASIN-1 (1678515-13-3) selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene.1 IC50 = 70nM for DLD1 cell line.? It inhibited cancer cell growth in human tumor xenografts (DLD1 and HT29 tumors) and a genetically engineered mouse model (CPC;Apc) of colorectal cancer.? TASIN-1 induces ER stress-dependent JNK activation with ROS production and AKT inhibition via cholesterol depletion.2
References
Zhang et al. (2016), Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer; Sci. Transl. Med., 8 361ra140 Zhang et al. (2016), Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells; Mol. Cancer Ther., 17 943
Properties of TASIN-1 hydrochloride
| storage temp. | -20°C |
| solubility | Soluble in DMSO (20 mg/ml) |
| form | solid |
| color | White to off-white |
| Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
Safety information for TASIN-1 hydrochloride
Computed Descriptors for TASIN-1 hydrochloride
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