TALIPEXOLE
- CAS NO.：101626-70-4
- Empirical Formula: C10H15N3S
- Molecular Weight: 209.31
- MDL number: MFCD00867565
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-11 19:39:08
What is TALIPEXOLE?
Description
Domin was launched in Japan for Parkinson's disease. The compound is readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its antiparkinson activity resides in the fact that talipexole is a selective agonist for presynaptic dopamine D2 receptors with no D1 receptor activity. It is a clonidine-like α2-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most widely used dopamine angonist. Also it is 70 times more potent than bromocriptine and has a more rapid onset of action. In addition to its anti-tremor activity there was a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT3 receptor antagonistic activity. Its metabolites have no biological activity, there was no development of tolerence and its effect could be enhanced by L-dopa.
Originator
Boehringer Ingelheim (Germany)
Definition
ChEBI: 6-prop-2-enyl-4,5,7,8-tetrahydrothiazolo[4,5-d]azepin-2-amine is an azepine.
brand name
Domin
Properties of TALIPEXOLE
| Boiling point: | 364.6±37.0 °C(Predicted) |
| Density | 1.167±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 7.22±0.20(Predicted) |
Safety information for TALIPEXOLE
Computed Descriptors for TALIPEXOLE
New Products
2-(2-Chlorophenyl)glycine Propiolic Acid trans-3-Benzyloxy-4-methoxy-beta-nitrostyrene 1-(3-Hydroxy-4-methoxyphenyl)-2-nitroethene (±)-amino(2-fluorophenyl)acetic acid 1-Pentadecanol N-cyanoacetylurethane 4-(4-Αminophenyl)-3-Morpholinone 3-Morpholino-1-(4-(2-oxopiperidin-1-yl) phenyl)-5,6-dihyropyridin-2-(1H)-one 1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one 1H-IndazoleRelated products of tetrahydrofuran
![5,6,7,8-TETRAHYDRO-4H-THIAZOLO[4,5-D]AZEPINE](https://img.chemicalbook.in/CAS/GIF/391953-91-6.gif)
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