TALAMPICILLIN
- CAS NO.：47747-56-8
- Empirical Formula: C24H23N3O6S
- Molecular Weight: 481.52
- MDL number: MFCD00869410
- EINECS: 256-332-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-12 17:19:15
What is TALAMPICILLIN?
Originator
Talpen,Beecham,US,1975
The Uses of TALAMPICILLIN
Antibacterial.
Definition
ChEBI: Talampicillin is a penicillanic acid ester that is the 1-phthalidyl ester of ampicillin. It is a prodrug of ampicillin. It has a role as a prodrug. It is functionally related to an ampicillin and an o-phthalaldehydic acid.
Manufacturing Process
A fine suspension of 25.18 grams (0.05 mol) of potassium salt of enamine protected ampicillin and 10.65 grams (0.05 mol) 3-bromophthalide were reacted in a 1:2 mixture of acetone/ethyl acetate (1,500 ml) for 24 hours. After filtration the organic layer was washed twice with 250 ml portions of 1 N sodium bicarbonate and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo. Addition of ether crystallized the phthalide enamine protected α-aminophenylacetamido penicillanate in 85% yield.
Therapeutic Function
Antibacterial
Properties of TALAMPICILLIN
| Boiling point: | 770.9±60.0 °C(Predicted) |
| Density | 1.48±0.1 g/cm3(Predicted) |
| pka | 12.15±0.60(Predicted) |
Safety information for TALAMPICILLIN
Computed Descriptors for TALAMPICILLIN
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