TAK-828F
- CAS NO.：1854901-94-2
- Empirical Formula: C28H32FN3O5
- Molecular Weight: 509.57
- MDL number: MFCD31813652
- Update Date: 2025-04-18 09:52:41
What is TAK-828F?
Description
TAK-828F is a potent and selective orally available RORγt inverse agonist. TAK-828F showed Binding IC50 = 1.9 nM; Reporter gene IC50=6.1 nM; logD=3.53; LLE (reporter gene)=4.68. TAK-828F inhibited IL-17 production from mouse splenocytes and human peripheral blood mononuclear cells dose-dependently at concentrations of 0.01-10?μM without affecting the production of IFN-γ. TAK-828F may provide a novel therapeutic option to treat immune diseases by inhibiting Th17 and Th1/17 cells' differentiation and improving imbalance between Th17 and Treg cells.
Properties of TAK-828F
| Boiling point: | 738.8±60.0 °C(Predicted) |
| Density | 1.322±0.06 g/cm3(Predicted) |
| pka | 4.72±0.10(Predicted) |
Safety information for TAK-828F
Computed Descriptors for TAK-828F
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