Tak 799
- CAS NO.：229005-80-5
- Empirical Formula: C33H39N2O2.Cl
- Molecular Weight: 531.136
- MDL number: MFCD05662319
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-29 13:23:30
What is Tak 799?
The Uses of Tak 799
TAK-779 has been used to inhibit CC chemokine ligand 5 (CCL5)– C-C chemokine receptor type 5 (CCR5) interaction in vitro in natural killer (NK) cytotoxicity assay. It has also been used as a blocker of CCR5 to study its effects and to evaluate the opening of the Panx-1 channels on peripheral blood mononuclear cells (PBMCs) isolated from human immunodeficiency virus (HIV)-infected individuals.
Biochem/physiol Actions
TAK-779 is a potent, dual antagonist at chemokine receptors C-C chemokine receptor type 2 (CCR2) and C-C chemokine receptor type 5 (CCR5) with IC50 = 1.4 nM at CCR5 and 2.3 nM at CCR2. Antagonists of both CCR2 and CCR5 such as TAK-779 have been investigated for treatment of viruses, rheumatoid arthritis, multiple sclerosis, and cancer. CCR5 is particularly targeted for anti-HIV therapy, since HIV entry into cells requires chemokine coreceptors CCR5 and C-X-C motif chemokine receptor 4 (CXCR4).
Storage
Store at -20°C
Properties of Tak 799
| storage temp. | 2-8°C |
| solubility | H2O: soluble3mg/mL, clear (warmed) |
| form | powder |
| color | white to beige |
Safety information for Tak 799
Computed Descriptors for Tak 799
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