TAK-063

CAS NO.：1238697-26-1
Empirical Formula: C23H17FN6O2
Molecular Weight: 428.42
MDL number: MFCD28385852
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-14 16:49:18

What is TAK-063?

Description

TAK-063 is a potent inhibitor of phosphodiesterase 10A (PDE10A; IC₅₀ = 0.3 nM). It is >15,000-fold selective for PDE10A over other PDEs and exhibits <50% inhibition at 91 receptors, ion channels, and enzymes at a concentration of 10 μM. TAK-063 (0.3 mg/kg) increases cAMP and cGMP levels by 1.3- and 2.14-fold, respectively, in the striatum of mice. It reverses hyperlocomotion induced by PCP (Item Nos. 14276 | ISO60194) with a minimum effective dose (MED) of 0.3 mg/kg, p.o., in wild-type mice but has no effect in PDE10A knockout mice at doses up to 1 mg/kg. TAK-063 also reverses hyperlocomotion induced by (+)-MK-801 (MED = 0.1 mg/kg, p.o.) but has no effect on plasma prolactin or glucose levels in rats.

Properties of TAK-063

Boiling point:	612.3±65.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:55.0(Max Conc. mg/mL);128.38(Max Conc. mM)
form	A crystalline solid
pka	-0.34±0.12(Predicted)
color	Light yellow to yellow

Safety information for TAK-063

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.