SU-11752
- CAS NO.：688036-19-3
- Empirical Formula: C26H27N3O5S
- Molecular Weight: 493.58
- Update Date: 2026-07-27 08:51:06
What is SU-11752?
Description
SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited.
Safety information for SU-11752
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