STATIL

CAS NO.：72702-95-5
Empirical Formula: C17H12BrFN2O3
Molecular Weight: 391.19
MDL number: MFCD00204117
SAFETY DATA SHEET (SDS)
Update Date: 2026-03-13 23:13:44

What is STATIL?

Description

Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with K_i values of 7.7 nM and 60 μM, respectively. Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats. Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F_2α by human cultured preadipocytes.

The Uses of STATIL

Statil is a knon aldose reductase inhibitor which blocks the conversion of glucose to sorbitol. In addition it suppresses cell cancer growth

The Uses of STATIL

Inhibitor (aldose reductase).

What are the applications of Application

Statil is an aldose reductase inhibitor

Definition

ChEBI: 2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxo-1-phthalazinyl]acetic acid is a member of phthalazines.

Biological Activity

Potent aldose reductase inhibitor.

Properties of STATIL

Melting point:	184-186℃ (DEC.)
Density	1.60
storage temp.	Store at RT
solubility	DMF: 2 mg/mL; DMSO: 2 mg/mL; Ethanol: 2 mg/mL; PBS (pH 7.2): 0.2 mg/mL
form	A crystalline solid
color	White to off-white

Safety information for STATIL

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.