SR 1903

CAS NO.：1414248-06-8
Empirical Formula: C27H27F6N3O
Molecular Weight: 523.52
Update Date: 2026-01-05 11:31:08

What is SR 1903?

Description

SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated receptor γ (PPAR) but does not activate it. SR-1903 inhibits LPS-induced expression of triggering receptor expressed on myeloid cells 1 (TREM-1). It also inhibits LPS-induced expression of the LXR target genes IL-6 and IL-33 and increases expression of ABCG1, FASN, and SCD-1. SR-1903 reduces the severity of collagen-induced arthritis. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity.

Properties of SR 1903

Boiling point:	559.0±50.0 °C(Predicted)
Density	1.307±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
form	A crystalline solid
pka	9.23±0.15(Predicted)

Safety information for SR 1903

Computed Descriptors for SR 1903

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