SQUALESTATIN
Synonym(s):L -694,599;Squalestatin
- CAS NO.：144541-82-2
- Empirical Formula: C35H47NaO14
- Molecular Weight: 714.74
- MDL number: MFCD03788025
- Update Date: 2026-01-13 11:25:01
What is SQUALESTATIN?
The Uses of SQUALESTATIN
Zaragozic acid A trisodium salt is a potent inhibitor of squalene synthase.
The Uses of SQUALESTATIN
Zaragozic acid A trisodium salt has been used as:
- a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
- a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
- a cholesterol synthesis inhibitor in T cells
What are the applications of Application
Zaragozic acid A trisodium salt is a potent inhibitor of squalene synthase. It has been used as a cholesterol synthesis inhibitor in T cells.
Biochem/physiol Actions
Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.
Properties of SQUALESTATIN
| storage temp. | -20°C |
Safety information for SQUALESTATIN
Computed Descriptors for SQUALESTATIN
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