Spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine, N-[(3-chlorophenyl)methyl]-, hydrochloride (1:1)

CAS NO.：2250025-95-5
Empirical Formula: C19H22Cl2N4
Molecular Weight: 377.31
Update Date: 2026-04-24 14:58:11

What is Spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine, N-[(3-chlorophenyl)methyl]-, hydrochloride (1:1)?

Biological Activity

Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor (IC50 = 22 nM). Protects human renal proximal tubule cells from 1S,3R-RSL3 -induced cell death in vitro. Inhibits acute renal failure and prolongs survival in Gpx4 knockdown mice. Also mitigates tissue damage in an in vivo hepatic ischemia/reperfusion model.

Storage

Store at -20°C

Properties of Spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine, N-[(3-chlorophenyl)methyl]-, hydrochloride (1:1)

solubility

Soluble to 100 mM in DMSO

Safety information for Spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine, N-[(3-chlorophenyl)methyl]-, hydrochloride (1:1)

Computed Descriptors for Spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine, N-[(3-chlorophenyl)methyl]-, hydrochloride (1:1)

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