SPDP-PEG12-NHS ester
- CAS NO.：2601437-72-1
- Empirical Formula: C39H65N3O17S2
- Molecular Weight: 912.07
- MDL number: MFCD13185005
- Update Date: 2026-03-18 11:52:23
What is SPDP-PEG12-NHS ester?
Biological Activity
SPDP-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of SPDP-PEG12-NHS ester
| Density | 1.26±0.1 g/cm3(Predicted) |
| pka | 15.01±0.46(Predicted) |
Safety information for SPDP-PEG12-NHS ester
Computed Descriptors for SPDP-PEG12-NHS ester
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