Sorbinil
- CAS NO.：68367-52-2
- Empirical Formula: C11H9FN2O3
- Molecular Weight: 236.2
- MDL number: MFCD00867380
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is Sorbinil?
The Uses of Sorbinil
Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.
The Uses of Sorbinil
Enzyme inhibitor (aldose reductase).
Definition
ChEBI: An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.
Biochem/physiol Actions
Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.
Properties of Sorbinil
| Melting point: | 241-243° |
| alpha | D25 +54.0° (c = 1 in methanol) |
| Density | 1.52 |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| pka | 8.91±0.20(Predicted) |
| color | white to off-white |
| optical activity | [α]/D +50 to +60°, c = 1 in methanol |
Safety information for Sorbinil
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for Sorbinil
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