Sobuzoxane
- CAS NO.：98631-95-9
- Empirical Formula: C22H34N4O10
- Molecular Weight: 514.53
- MDL number: MFCD00866498
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-17 18:22:24
What is Sobuzoxane?
Description
Sobuzoxane, a novel bis(2,6-dioxopiperazine) derivative, was introduced in Japan for the treatment of malignant lymphoma and adult T-cell IeukemiaQmphoma (ATLL), which is resistant to chemotherapy and has a poor prognosis. Sobuzoxane exhibits 8 broad spectrum of antitumor activity. It is a noncleavable complexstabilizing topoisomerase II inhibitor and exerts its function via interfering with the catalytic activity of the enzyme to result in an irreversible inhibition of cell division by blockade of chromosome condensation and segregation. Due to Its unique mode of cytocidai activity, it has no cross resistance with many currently available anticancer agents. Sobuzoxane is reported to significantly inhibit growth of human colon, lung, gastric, and breast cancers and is in clinical trials for these indications.
Originator
Zenyaku Kogyo (Japan)
The Uses of Sobuzoxane
Sobuzoxane is an inhibitor of DNA topoisomerase II which induces apoptosis.
What are the applications of Application
Sobuzoxane is an inhibitor of Topo II (DNA topoisomerase II) which induces apoptosis
Definition
ChEBI: Sobuzoxane is an organic molecular entity.
brand name
Perazolln
Properties of Sobuzoxane
| Melting point: | 128-130°; mp 132-133° (Cai, 1989) |
| Boiling point: | 664.9±55.0 °C(Predicted) |
| Density | 1.272±0.06 g/cm3(Predicted) |
| solubility | DMSO: 19 mg/mL |
| form | solid |
| pka | 2.75±0.20(Predicted) |
Safety information for Sobuzoxane
Computed Descriptors for Sobuzoxane
New Products
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