SMKXBJMWSIFUAU-YKNYVSNTSA-N

CAS NO.：1283861-32-4
Empirical Formula: C20H32O4
Molecular Weight: 336.47
Update Date: 2026-05-28 05:25:17

What is SMKXBJMWSIFUAU-YKNYVSNTSA-N?

Description

Bicyclo Prostaglandin E₁ (bicyclo PGE₁) is a stable, base-catalyzed transformation product of the PGE₁ metabolite 13,14-dihydro-15-keto PGE₁. 13,14-dihydro-15-keto PGE₁ itself is a metabolite of PGE₁^1,2 found in human plasma at a median level of 10 pg/ml.³ Due to the inherent instability of 13,14-dihydro-15-keto PGE₁, it is advisable to quantify it as bicyclo PGE₁ to estimate PGE₁ biosynthesis or metabolism in vivo.

References

1. Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E₁ and E₂ in man J. Biol. Chem. 246(22),6713-6721(1971).
2. Peskar, B.A., Cawello, W., Rogatti, W., et al. On the metabolism of prostaglandin E₁ administered intravenously to human volunteers J. Physiol. Pharmacol. 42,327-331(1991).
3. Leonhardt, A., Krauss, M., Gieler, U., et al. In vivo formation of prostaglandin E₁ and prostaglandin E₂ in atopic dermatitis Br. J. Dermatol. 136(3),337-340(1997).

Properties of SMKXBJMWSIFUAU-YKNYVSNTSA-N

Boiling point:	509.4±25.0 °C(Predicted)
Density	1.054±0.06 g/cm3(Predicted)
solubility	DMF: >25 mg/ml (from Bicyclo PGE2); DMSO: >25 mg/ml (from Bicyclo PGE2); Ethanol: >30 mg/ml (from Bicyclo PGE2); PBS pH 7.2: >1.4 mg/ml (from Bicyclo PGE2)
pka	4.77±0.10(Predicted)

Safety information for SMKXBJMWSIFUAU-YKNYVSNTSA-N

Computed Descriptors for SMKXBJMWSIFUAU-YKNYVSNTSA-N

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