Smad3 Inhibitor, SIS3
- CAS NO.：1009104-85-1
- Empirical Formula: C28H27N3O3
- Molecular Weight: 453.53
- MDL number: MFCD24368989
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 00:05:46
What is Smad3 Inhibitor, SIS3?
The Uses of Smad3 Inhibitor, SIS3
SMAD3 Inhibitor, SIS3 selectively inhibits TGF-β and activin. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
What are the applications of Application
Smad3 Inhibitor, SIS3 is a cell permeable pyrrolopyridine and selective inhibitor of TGF-β1-dependent Smad3 phosphorylation
Definition
ChEBI: An enamide resulting from the formal condensation of the amino group of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline with the carboxy group of (2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acrylic cid.
Properties of Smad3 Inhibitor, SIS3
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.2 mg/ml |
| form | A crystalline solid |
Safety information for Smad3 Inhibitor, SIS3
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Smad3 Inhibitor, SIS3
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