SM16
- CAS NO.：614749-78-9
- Empirical Formula: C25H26N4O3
- Molecular Weight: 430.5
- Update Date: 2026-07-27 17:00:41
What is SM16?
Biological Activity
SM 16 is an ALK5/ALK4 kinase inhibitor with Ki values of 10 and 1.5 nM, respectively.
in vivo
SM 16 penetrates tumor cells in vivo , suppressing tumor phosphorylated Smad2/3 levels for at least 3 h following treatment of tumor-bearing mice with a single ip bolus of 20 mg/kg SM 16. The growth of established AB12 tumors is significantly inhibited by 5 mg/kg/d SM 16 (P<0.001) delivered via sc miniosmotic pumps over 28 days.
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Storage
Store at -20°C
Properties of SM16
| Boiling point: | 691.3±55.0 °C(Predicted) |
| Density | 1.354±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:65.0(Max Conc. mg/mL);150.99(Max Conc. mM) |
| form | A solid |
| pka | 11.23±0.10(Predicted) |
| color | White to off-white |
Safety information for SM16
Computed Descriptors for SM16
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