SirReal2

CAS NO.：709002-46-0
Empirical Formula: C22H20N4OS2
Molecular Weight: 420.55
MDL number: MFCD04173051
SAFETY DATA SHEET (SDS)
Update Date: 2025-08-20 16:56:15

What is SirReal2?

Description

Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC₅₀ = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.

The Uses of SirReal2

SirReal2 is an aminothiazole that is a potent and selective Sirt2 inhibitor.

Storage

Store at -20°C

Properties of SirReal2

storage temp.	Store at -20°C
solubility	DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
form	A crystalline solid
color	Off-white to light yellow

Safety information for SirReal2

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.