SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE

Description

Sibutramine was introduced as Meridia in the US for the control of obesity, in conjunction with a reduced-calorie diet. Sibutramine can be prepared in four steps from 4-chlorobenzyl cyanide. Sibutramine acts as a serotonin and noradrenaline reuptake inhibitor ; in animal studies, it reduces energy intake by creating a satieted feeling and increases energy expenditure by enhancing thermogenesis. In a clinical study in obese patients treated with 10 or 15 mg of Sibutramine once-daily, meaningful weight loss was sustained for 12 months ; an additional study demonstrated a lack of abuse potential. An appreciable part of Sibutramine's effect would also be due to its 2N-mono and didesmethylmetabolites, which are very potent monoamine reuptake inhibitors themselves.

Chemical properties

White Solid

Originator

Knoll (Germany)

The Uses of SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE

A serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure

The Uses of SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE

antiobesity agent;neurotransmitter reuptake inhibitor

The Uses of SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE

antihyperlipidemic

brand name

Meridia (Abbott);Meridia, Reductil.