SIB 1893
Synonym(s):[E]-2-Methyl-6-[2-phenylethenyl]pyridine
- CAS NO.：6266-99-5
- Empirical Formula: C14H13N
- Molecular Weight: 195.26
- MDL number: MFCD02262120
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-22 18:57:36
What is SIB 1893?
The Uses of SIB 1893
SIB 1893 is a selective antagonist of mGluR-5. SIB 1893 acts as a positive allosteric modulator of human metabotropic mGlu4 (1). Anticonvulsant (2).
What are the applications of Application
SIB 1893 is a selective antagonist of mGluR-5
Definition
ChEBI: 2-methyl-6-(2-phenylethenyl)pyridine is a member of styrenes.
Biological Activity
A highly selective non-competitive antagonist for the metabotropic glutamate mGlu 5 receptor subtype; displays an IC 50 value of 0.3 μ M? at hmGlu 5 , compared with > 100 μ M at hmGlu 1b , hmGlu 2 , hmGlu 6 , hmGlu 7 and hmGlu 8 . Centrally active upon systemic administration in vivo . Positive allosteric modulator at mGlu 4 receptors.
Properties of SIB 1893
| storage temp. | 2-8°C |
| solubility | DMSO: 18 mg/mL |
| form | solid |
| color | White to off-white |
Safety information for SIB 1893
Computed Descriptors for SIB 1893
New Products
Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 2-Bromo-5-hydroxybenzoic acid. 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 4-Fluorophenylglycine 1-N-Boc-3-(aminoethyl)azetidine Dimedone 1-Boc-3-(cyanomethyl)azetidine N-BOC-piperidine-4-carboxylic acid 1-Benzhydrylazetane-3-carbonitrile 5-Amino-2-Hydroxypyridine 2-Amino-5-Iodopyridine 2-BROMOACETYL BROMIDE-D2 METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3 6-Chloro-pyrimidine-2,4-diamine 3-Oxide 1-Acetyl-4-(4-hydroxyphenyl)piperazine 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
![4-(1,3-BENZODIOXOL-5-YL)-2-(4-NITROSTYRYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE](https://img.chemicalbook.in/StructureFile/ChemBookStructure7/GIF/CB1117497.gif)
![4-(1,3-BENZODIOXOL-5-YL)-2-(4-HYDROXYSTYRYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE](https://img.chemicalbook.in/StructureFile/ChemBookStructure7/GIF/CB0178965.gif)
![4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(2-FLUOROPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE](https://img.chemicalbook.in/StructureFile/ChemBookStructure7/GIF/CB1776366.gif)
![2-[(E)-2-(3-CHLOROPHENYL)ETHENYL]-4-(4-HEPTYLPHENYL)-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE](https://img.chemicalbook.in/StructureFile/ChemBookStructure6/GIF/CB1450639.gif)
![4-(2-FLUOROPHENYL)-2-[(E)-2-(3-METHOXYPHENYL)ETHENYL]-5-OXO-5H-INDENO[1,2-B]PYRIDINE-3-CARBONITRILE](https://img.chemicalbook.in/StructureFile/ChemBookStructure6/GIF/CB1255414.gif)
![4-(1,3-BENZODIOXOL-5-YL)-2-[(E)-2-(4-CHLOROPHENYL)ETHENYL]-5H-INDENO[1,2-B]PYRIDIN-5-ONE](https://img.chemicalbook.in/StructureFile/ChemBookStructure7/GIF/CB6686961.gif)
You may like
-
350-03-8 3-AcetylpyridineView Details
350-03-8 -
1-(4-Aminophenyl)-4-(4-methoxyphenyl)Piperazine 74852-62-3View Details
74852-62-3 -
556-08-1 4-Acetamidobenzoic acidView Details
556-08-1 -
5-Bromo-2-Chlorobenzoic acid 21739-92-4View Details
21739-92-4 -
15128-52-6View Details
15128-52-6 -
36476-86-5 1-Benzhydrylazetane-3-carbonitrile 98+View Details
36476-86-5 -
36476-86-5 1-Benzhydrylazetane-3-carbonitrile 98+View Details
36476-86-5 -
36476-86-5 1-Benzhydrylazetane-3-carbonitrile 98+View Details
36476-86-5
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.