SIB 1757
Synonym(s):6-Methyl-2-(phenylazo)-3-pyridinol
- CAS NO.：31993-01-8
- Empirical Formula: C12H11N3O
- Molecular Weight: 213.24
- MDL number: MFCD00506102
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is SIB 1757?
The Uses of SIB 1757
SIB 1757 is an antagonist for mGluR-5.
What are the applications of Application
SIB 1757 is an antagonist for mGluR-5
Definition
ChEBI: 6-methyl-2-(phenylhydrazinylidene)-3-pyridinone is a member of phenylhydrazines.
Biological Activity
A highly selective antagonist for the mGlu 5 metabotropic glutamate receptor subtype; displays an IC 50 value of 0.4 μ M at hmGlu 5 compared with > 30 μ M at hmGlu 1b , hmGlu 2 , hmGlu 4 , hmGlu 6 , hmGlu 7 and hmGlu 8 .
Properties of SIB 1757
| storage temp. | Store at RT |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | crystalline |
| color | red |
Safety information for SIB 1757
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for SIB 1757
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