Sevelamer hydrochloride

Originator

Renagel,Chugai Pharmaceutical

The Uses of Sevelamer hydrochloride

Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure.

The Uses of Sevelamer hydrochloride

Sevelamer HCl is used in the treatment of hyperphosphataemia in patients suffering from chronic kidney disease.

The Uses of Sevelamer hydrochloride

Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure or patients suffering from chronic kidney disease.

What are the applications of Application

Sevelamer Hydrochloride is a noncalcemic phosphate binder

Definition

ChEBI: Sevelamer hydrochloride is an epoxide.

Manufacturing Process

Poly(allylamine hydrochloride) (50% w/w, 426 kg) was charged to a 1000 L reactor and water (200 L) was added. Sodium hydroxide solution (32% w/w, 208 kg) was added, followed by 85 L of water. The mixture was stirred for 1 h and filtered to a 2500 L reactor. The transfer line was rinsed with water (217 kg) and acetonitrile (1300 L) added. The temperature was adjusted to 40°C and epichlorohydrin (20 kg) added. The mixture was stirred at 40° to 50°C for 1.5 h and then heated to reflux for 16 h. The resulting product slurry may be isolated and washed in decanter centrifuge.

brand name

Renagel (Genzyme).

Therapeutic Function

Antihyperphosphatemic

Veterinary Drugs and Treatments

Sevalamer may be useful for treating hyperphosphatemia associated with chronic renal failure, particularly when oral aluminum salts are not tolerated.