SCUTELLAREIN
Synonym(s):4′,5,6,7-Tetrahydroxyflavone;6-Hydroxyapigenin
- CAS NO.：529-53-3
- Empirical Formula: C15H10O6
- Molecular Weight: 286.24
- MDL number: MFCD00017692
- EINECS: 1806241-263-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-21 16:49:52
What is SCUTELLAREIN?
Description
Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities. It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml. Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively). It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM. In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.
Chemical properties
Yellow solid
The Uses of SCUTELLAREIN
Scutellarein is a flavonoid that can be found in Scutellaria lateriflora. Scutellarein is a hydrolysis product of Scutellarein (S201900), its glucuronide conjugated analogue.
Definition
ChEBI: Flavone substituted with hydroxy groups at C-4', -5, -6 and -7.
Properties of SCUTELLAREIN
| Melting point: | 330°C |
| Boiling point: | 642.9±55.0 °C(Predicted) |
| Density | 1.654±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: soluble1mg/mL, clear, greenish-yellow |
| pka | 6.34±0.40(Predicted) |
| form | powder |
| color | yellow |
Safety information for SCUTELLAREIN
Computed Descriptors for SCUTELLAREIN
| InChIKey | JVXZRQGOGOXCEC-UHFFFAOYSA-N |
New Products
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