Sclareol
Synonym(s):(1R,2R,8aS)-Decahydro-1-(3-hydroxy-3-methyl-4-pentenyl)-2,5,5,8a-tetramethyl-2-naphthol;Labd-14-ene-8,13-diol
- CAS NO.：515-03-7
- Empirical Formula: C20H36O2
- Molecular Weight: 308.51
- MDL number: MFCD00869558
- EINECS: 208-194-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:16:29
What is Sclareol?
The Uses of Sclareol
Sclareol is used in biological studies as it has anti-inflammatory activity in both lipopolysaccharide-stimulated macophages and λ-carrageenan-induced paw edema model.
The Uses of Sclareol
antineoplastic, apoptosis inducer
The Uses of Sclareol
Sclareol may be used as a starting material in the synthesis of ambergris fragrance chemicals such as ambraoxide, ambrox, methylambraoxide, ambracetal, ambraketal and epiambraketal. It may also be used in the synthesis of (+)-galanolactone, (-)-8-epi-galanolactone and (+)-labdienedial.
Definition
ChEBI: A labdane diterpenoid that is labd-14-ene substituted by hydroxy groups at positions 8 and 13. It has been isolated from Salvia sclarea.
General Description
Sclareol, a diterpene compound with a labdane skeleton, is mainly used as a raw material in the fragrance industry. It shows potent cytotoxic and cytostatic effect in human leukemic cell lines.
Cytotoxicity
IC50 (μg/mL): 16.6 (HeLa), 32.65 (MCF7),65.2 μM (MG63) (Farimani et al. 2014).
Properties of Sclareol
| Melting point: | 95-100 °C (lit.) |
| Boiling point: | 218-220 °C/19 mmHg (lit.) |
| alpha | -13 º (c=4, in carbon tetrachloride) |
| Density | 0.954±0.06 g/cm3(Predicted) |
| FEMA | 4502 | (-)-SCLAREOL |
| storage temp. | 2-8°C |
| solubility | Chlorform, Ethyl Acetate (Slightly) |
| form | neat |
| pka | 14.49±0.29(Predicted) |
| form | Solid |
| color | White to Off-White |
| Odor | at 100.00 %. sweet balsam clary amber woody weedy |
| optical activity | [α]25/D 13°, c = 4 in carbon tetrachloride |
| JECFA Number | 2029 |
| BRN | 2054148 |
| CAS DataBase Reference | 515-03-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Naphthalenepropanol, «alpha»-ethenyldecahydro-2-hydroxy-«alpha»,2,5,5,8a-pentamethyl-, [1r-[1«alpha»(r*),2«beta»,4a«beta»,8a«alpha»]]-(515-03-7) |
| EPA Substance Registry System | Sclareol (515-03-7) |
Safety information for Sclareol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Sclareol
| InChIKey | XVULBTBTFGYVRC-HHUCQEJWSA-N |
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