Schisandrin A
Synonym(s):Deoxyschisandrin;Deoxyschizandrin;Dimethylgomisin J;Schisandrin A;Schizandrin A
- CAS NO.：61281-38-7
- Empirical Formula: C24H32O6
- Molecular Weight: 416.51
- MDL number: MFCD00221760
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:59:02
What is Schisandrin A?
Description
Schisandrin A is a lignan that has been found in Schisandra and has diverse biological activities. It binds to adiponectin receptor 2 (IC50 = 3.2 μM). Schisandrin A (10, 20, and 50 μM) reduces LPS-induced production of nitric oxide (NO), IL-6, and TNF-α and apoptosis in primary mouse microglial cells. It reverses P-glycoprotein-mediated doxorubicin resistance in MCF-7/dox cells when used at a concentration of 20 μM. Schisandrin A (4, 12, and 36 mg/kg) reverses short-term and spatial memory deficits, as well as decreases in cerebral superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities induced by amyloid β (1-42) (Aβ42; ) in a mouse model of Alzheimer’s disease.
Chemical properties
White powder
The Uses of Schisandrin A
Schizandrin A is an extract from Schisandra chinesis. a dibenzocyclooctadiene lignan with antiinflammatory activity.
What are the applications of Application
Deoxyschizandrin is an agonist of the adiponectin receptor 2 (AdipoR2)
Properties of Schisandrin A
| Melting point: | 116-117 °C |
| Boiling point: | 544.2±50.0 °C(Predicted) |
| Density | 1.080±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | powder |
| color | White to Off-White |
Safety information for Schisandrin A
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Schisandrin A
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