SC 19220
Synonym(s):2-Acetylhydrazide 10(11H)-carboxylic acid;8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid
- CAS NO.：19395-87-0
- Empirical Formula: C16H14ClN3O3
- Molecular Weight: 331.75
- MDL number: MFCD02259329
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-11 19:39:08
What is SC 19220?
The Uses of SC 19220
SC 19220 is a selective EP1?receptor antagonist.
The Uses of SC 19220
SC 19220 was used to study the role of prostaglandin E2 in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures.
What are the applications of Application
SC 19220 is a selective EP1 receptor antagonist
Definition
ChEBI: N'-acetyl-3-chloro-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide is an aromatic ether.
Biological Activity
Selective EP 1 receptor antagonist (IC 50 = 6.7 μ M for inhibition of [ 3 H]-PGE 2 binding to EP 1 transfected COS cells).
Biochem/physiol Actions
SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α. SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6.
Storage
Store at RT
Properties of SC 19220
| Melting point: | 190-191 °C (lit.) |
| storage temp. | Store at RT |
| solubility | DMSO: 10 mg/mL, soluble |
| form | solid |
| color | white |
Safety information for SC 19220
Computed Descriptors for SC 19220
New Products
Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) Cis-Tosylate Dibenzo[b,f][1,4]thiazepin-11(10H)-one 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) BOC Piperazine 1-Benzhydrylazetane-3-carbonitrile 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione (±)-amino(2-fluorophenyl)acetic acid 2-(2-Chlorophenyl)glycine AMINO-(3-CHLORO-PHENYL)-ACETIC ACID 2'-Fluoroacetophenone METHANOL-D1(OD) TERTIARY BUTANOL-D9 N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D CHLOROFORM-D TOLUENE-D3 Trans,trans muconic acid HC Blue-16 4-Amino-2-chloro-6,7-dimethoxyquinazoline Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate 2,3-Dimethoxypyridine 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
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