SB 242084 (hydrochloride)

CAS NO.：1049747-87-6
Empirical Formula: C21H21Cl3N4O2
Molecular Weight: 467.77604
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:24:41

What is SB 242084 (hydrochloride)?

Description

Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that activates specific receptors located primarily in the gut and central nervous system. SB-242084 is an antagonist of the 5-HT_2C receptor (pK_i = 9.0), with at least 100-fold more selectivity over other 5-HT, dopamine, or adrenergic receptors. In vivo, it is brain penetrant and has significant anxiolytic activity, without sedative, proconvulsant, or hyperphagic properties. SB-242084 has been used extensively in animal research to evaluate, for example, 5-HT_2C receptor agonists and neurotransmitter receptor interactions in mice.

The Uses of SB 242084 (hydrochloride)

SB 242084 Hydrochloride is an antagonist of the SR-2C.

What are the applications of Application

SB 242084 hydrochloride is an antagonist of the SR-2C

Definition

ChEBI: 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride is an organic molecular entity, an indole alkaloid and a pyridine. It has a role as a receptor modulator.

Storage

Desiccate at +4°C

Properties of SB 242084 (hydrochloride)

storage temp.	Sealed in dry,Room Temperature
solubility	Ethanol:1.0(Max Conc. mg/mL);2.14(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);21.38(Max Conc. mM) DMSO:59.63(Max Conc. mg/mL);127.47(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);64.13(Max Conc. mM)
form	A crystalline solid
color	Off-white to light yellow