SB 218795
- CAS NO.：174635-53-1
- Empirical Formula: C25H20N2O3
- Molecular Weight: 396.44
- MDL number: MFCD00951240
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-17 18:22:24
What is SB 218795?
The Uses of SB 218795
SB 218795 is an NK3 receptor antagonist.
What are the applications of Application
SB 218795 is a potent and selective NK3 antagonist
Definition
ChEBI: (2R)-2-[[oxo-(2-phenyl-4-quinolinyl)methyl]amino]-2-phenylacetic acid methyl ester is a member of quinolines.
Biological Activity
Potent, selective and competitive non-peptide NK 3 receptor antagonist (K i = 13 nM at hNK 3 ). Displays 90-fold and 7000-fold selectivity over hNK 2 and hNK 1 receptors respectively. Active in vivo , inhibiting agonist-induced pupillary constriction.
Properties of SB 218795
| Boiling point: | 623.7±55.0 °C(Predicted) |
| Density | 1.237±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 40 mg/mL, soluble |
| form | solid |
| pka | 11.41±0.46(Predicted) |
| color | white |
Safety information for SB 218795
Computed Descriptors for SB 218795
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