SAfit2

CAS NO.：1643125-33-0
Empirical Formula: C46H62N2O10
Molecular Weight: 802.99
MDL number: MFCD31619236
Update Date: 2026-08-30 11:39:11

What is SAfit2?

Description

SAfit2 is a potent inhibitor of FK506-binding protein 51 (FKBP51; K_i = 6 nM). It is highly selective for FKBP51 over FKBP52 (K_i = >50,000 nM) and has increased brain permeability in comparison to SAfit1. SAfit2 (20 mg/kg) enhances HPA axis suppression in mice by decreasing plasma corticosterone levels to a greater extent than in control mice following dexamethasone administration. It also does not increase plasma corticosterone levels as high as in control mice following subsequent administration of corticotropin-releasing factor (CRF; ). It decreases the time spent immobile in the forced swim test and increases the time spent in the open arms of the elevated plus maze, indicating antidepressant-like and anxiolytic-like activity, respectfully.

The Uses of SAfit2

SAFit2 is a highly selective inhibitor of FKBP51. The selective inhibition of FKBP51, using SAFit1(S139583) & SAFit2 , has shown to enhances neurite elongation in neuronal cultures and improves neuroendocrine feedback and stress-coping behavior in mice.

Properties of SAfit2

Boiling point:	877.0±65.0 °C(Predicted)
Density	1.168±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
form	A crystalline solid
pka	6.43±0.10(Predicted)
color	Off-white to pink

Safety information for SAfit2

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P501:Dispose of contents/container to..…

Computed Descriptors for SAfit2

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