S1RA (hydrochloride)
- CAS NO.：1265917-14-3
- Empirical Formula: C20H24ClN3O2
- Molecular Weight: 373.88
- MDL number: MFCD27963345
- EINECS: 931-042-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-20 19:14:41
What is S1RA (hydrochloride)?
Description
S1RA (E-52862, 1265917-14-3) is a potent and selective σ1 antagonist with weak binding at σ2?(IC50?σ1 = 17nM, σ2 = 9300nM).1,2?S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a σ1 dependent manner.3?S1RA potentiated μ-opioid antinociception in mice in a σ-dependent manner.4?S1RA displayed neuroprotective effects in a mouse model of ischemic stroke.5
References
References/Citations
Properties of S1RA (hydrochloride)
| storage temp. | -20°C (des.) |
| solubility | Soluble in DMSO (up to at least 25 mg/ml) |
| form | solid |
| color | Off-white |
| Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Safety information for S1RA (hydrochloride)
Computed Descriptors for S1RA (hydrochloride)
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