S- (+)-Rolipram

CAS NO.：85416-73-5
Empirical Formula: C16H21NO3
Molecular Weight: 275.34
MDL number: MFCD03093861
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-17 09:03:53

What is S- (+)-Rolipram?

The Uses of S- (+)-Rolipram

S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer

The Uses of S- (+)-Rolipram

S-(+)-Rolipram is an inhibitor of cyclic AMP-specific phosphodiesterase. It is the S isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor

What are the applications of Application

S-(+)-Rolipram is an inhibitor of cyclic AMP-specific phosphodiesterase

Definition

ChEBI: The (S)-enantiomer of rolipram.

Biological Activity

Less active enantiomer of the PDE4 inhibitor rolipram (4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ).

Storage

Room temperature

Properties of S- (+)-Rolipram

Melting point:	133-136℃
Density	1.155
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO : 100 mg/mL (363.19 mM; Need ultrasonic)
form	White to off-white solid.
color	White to Almost white

Safety information for S- (+)-Rolipram

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.