(S)-(+)-KETOPINIC ACID

Synonym(s):(1S)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylic acid

CAS NO.：40724-67-2
Empirical Formula: C10H14O3
Molecular Weight: 182.22
MDL number: MFCD08061242
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-14 15:27:00

What is (S)-(+)-KETOPINIC ACID?

The Uses of (S)-(+)-KETOPINIC ACID

7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1-carboxylic Acid is a useful reactant for the preparation of alkenyl nitrile electrophiles for the possible use of covalent protein labeling.

The Uses of (S)-(+)-KETOPINIC ACID

(1S)-(+)-Ketopinic acid may be used to prepare:

Chiral phosphine-oxazoline ligands, which can used in asymmetric palladium-catalyzed Heck reaction of aryl or alkenyl triflates with cyclic alkenes.
A chiral imino-phosphine ligand, which can be used in palladium-catalyzed asymmetric Diels–Alder reactions to prepare six-membered carbocycles.
A chiral iminopyridine ligand, which can be used in copper-catalyzed Henry (nitro aldol) reaction between nitromethane and o-anisol to form the corresponding β-hydroxynitroalkane.

General Description

(1S)-(+)-Ketopinic acid is a chiral ketone.

Properties of (S)-(+)-KETOPINIC ACID

Melting point:	237-239 °C(lit.)
Boiling point:	313.3±25.0 °C(Predicted)
alpha	58 º (C=1 IN CHLOROFORM)
Density	1.238±0.06 g/cm3(Predicted)
refractive index	25.5 ° (C=0.65, MeOH)
storage temp.	Sealed in dry,Room Temperature
form	powder to crystal
pka	3.67±0.40(Predicted)
color	White to Almost white
optical activity	[α]23/D +58°, c = 1 in chloroform
BRN	4180005
CAS DataBase Reference	40724-67-2(CAS DataBase Reference)

Safety information for (S)-(+)-KETOPINIC ACID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.