(S)-AMPA
Synonym(s):(S)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid
- CAS NO.：83643-88-3
- Empirical Formula: C7H10N2O4
- Molecular Weight: 186.17
- MDL number: MFCD00672630
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 09:27:42
What is (S)-AMPA?
The Uses of (S)-AMPA
(S)-AMPA is an analogue for AMPA (A611500) a specific agonist for the AMPA receptor which mimics the glutamate receptor.
The Uses of (S)-AMPA
Active enantiomer of AMPA that induces apoptosis in cortical neurons
The Uses of (S)-AMPA
(S)-AMPA has also been used to activate rostromedial tegmental nucleus (RMTg), to study aversive conditioning in relation with cocaine-induced avoidance behaviors in mice.
What are the applications of Application
(S)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid is an active isomer of AMPA with no NMDAR activity
General Description
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) activates excitatory postsynaptic currents (EPSC).
Biological Activity
Active enantiomer of AMPA (EC 50 = 3.5 μ M). Also available as part of the AMPA Receptor Tocriset™ .
Biochem/physiol Actions
Active enantiomer of (RS)-AMPA zwitterion. Potent agonist at the AMPA subclass of ionotropic glutamate receptors.
Storage
Room temperature
Properties of (S)-AMPA
| alpha | D28 -21 ±2° (c = 0.19 in water) |
| Density | 1.386±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| form | White to off-white powder. |
| pka | 2.15±0.10(Predicted) |
| color | White |
| Water Solubility | Soluble to 100 mM in water |
| CAS DataBase Reference | 83643-88-3(CAS DataBase Reference) |
Safety information for (S)-AMPA
Computed Descriptors for (S)-AMPA
New Products
Mirtazapine Impurity C/Mirtazapine Lactam Impurity Cyclopropane-1,1-dicarboxylic acid [1]Benzothieno[2,3-c]pyridine, 1,7-dichloro-8-methyl- (S)-3-Fluoro-pyrrolidine hydrochloride Cyclobutylamine 1-Bromo-2-Methoxy-3-Nitrobenzene 3-Oxocyclobutane-1-carboxylicacid (4-Bromophenyl)(3,4-dimethoxyphenyl)methanone N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity 2-chloro-7-cyclopentyl-N,N-dimethylpyrrolo [2,3-d]pyrimidine-6-carbox amide 4-amino-2-fluoro-N- methylbenzamide N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H- indazol 6-amine 5-Chloro-3- Methyl -1,3-2-benzoxazol-2(3H)-one 4-Bromo-2-fluoro-N-methylbenzamide N-Boc-1,4-butanediamine 4-Dimethylamino pyridine 2-Chlorotrityl Chloride 4-Bromoaniline 5-Bromo-2-chlorobenzoic acid 1,2,3,9-Tetrahydro-4(H)-carbazol-4-oneRelated products of tetrahydrofuran
![ETHYL 2-ACETAMIDO-2-ETHOXYCARBONYL-3-[3-HYDROXY-5-METHYLISOXAZOL-4-YL]PROPANOATE](https://img.chemicalbook.in/StructureFile/ChemBookStructure8/GIF/CB3245824.gif)
![AMPA, S-(-)[5-METHYL-3H]-](https://img.chemicalbook.in/StructureFile/ChemBookStructure5/GIF/CB7350571.gif)
![ETHYL 2-ACETAMIDO-2-ETHOXYCARBONYL-3-[3-(ETHOXYCARBONYLMETHOXY)-5-METHYLISOXAZOL-4-YL]PROPANOATE](https://img.chemicalbook.in/StructureFile/ChemBookStructure8/GIF/CB0112147.gif)
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