(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
Synonym(s):(+)-MCPG;S(+)-α-Amino-4-carboxy-α-methyl-benzeneacetic acid
- CAS NO.：150145-89-4
- Empirical Formula: C10H11NO4
- Molecular Weight: 209.2
- MDL number: MFCD00216858
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:11
What is (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE?
Chemical properties
white to off-white solid
The Uses of (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
Active enantiomer of (±)-MCPG
What are the applications of Application
(S)-MCPG is a non-selective group I/II mGluR antagonist
Definition
ChEBI: (S)-alpha-methyl-4-carboxyphenylglycine is a non-proteinogenic alpha-amino acid that is alanine in which the alpha-hydrogen is replaced by a 4-carboxyphenyl group (the S-enantiomer). It is a non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. It has a role as a metabotropic glutamate receptor antagonist.
Biological Activity
Active isomer of (RS)-MCPG ((RS)-a-Methyl-4-carboxyphenylglycine ). Non-selective group I/group II metabotropic glutamate receptor antagonist. Also available as part of the Group I mGlu Receptor Tocriset™ , Group II mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .
Biochem/physiol Actions
(+)-α-Methyl-4-carboxyphenylglycine, also known as MCPG, is a competitive metabotropic glutamate receptor antagonist.
Storage
Room temperature
Properties of (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
| Boiling point: | 425.3±40.0 °C(Predicted) |
| Density | 1.390±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | 0.1 M NaOH: 15 mg/mL |
| form | solid |
| pka | 1.76±0.10(Predicted) |
| color | White to off-white |
| optical activity | [α]20/D +89.54°, c = 0.33 in 6 M HCl(lit.) |
Safety information for (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
Computed Descriptors for (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
New Products
DL-beta-(3-Bromophenyl)alanine 1-Aminocyclopentane carbonitrile (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid N,N CARBONYL DIIMIDAZOLE 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) Benzyl (3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate Amlodipine EP Impurity-C Budesonide Impurity-K/Budesonide 21-Acetate (Epimers) Gabapentine Impurity 72 Bicalutamide Impurity-B Betahistine EP Impurity C Carbamazepine EP Impurity G 2,2'-(5-methyl-1,3-phenylene)-di(2-Methylpropionitrile) 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene 5-Methyl-1,3-benzenediacetonitrile (R)-BoroLeu-(+)-Pinanediol-CF3COOH 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 3-Hydroxypropionitrile 4-Bromo Benzylcyanide valeronitrile 3,4 Dimethoxy Benzylcyanide 3-chlorobenzyl cyanide 2-Chloro BenzylcyanideRelated products of tetrahydrofuran
![Benzenemethanol, 4-[(1R)-1-aminoethyl]-](https://img.chemicalbook.in/CAS/GIF/925456-54-8.gif)
![(2S)-2-AMINO-2-[4-(METHOXYCARBONYL)PHENYL]PROPANOIC ACID](https://img.chemicalbook.in/StructureFile/ChemBookStructure9/GIF/CB6483199.gif)
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