(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
Synonym(s):(+)-MCPG;S(+)-α-Amino-4-carboxy-α-methyl-benzeneacetic acid
- CAS NO.：150145-89-4
- Empirical Formula: C10H11NO4
- Molecular Weight: 209.2
- MDL number: MFCD00216858
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-24 08:04:07
What is (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE?
Chemical properties
white to off-white solid
The Uses of (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
Active enantiomer of (±)-MCPG
What are the applications of Application
(S)-MCPG is a non-selective group I/II mGluR antagonist
Definition
ChEBI: (S)-alpha-methyl-4-carboxyphenylglycine is a non-proteinogenic alpha-amino acid that is alanine in which the alpha-hydrogen is replaced by a 4-carboxyphenyl group (the S-enantiomer). It is a non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. It has a role as a metabotropic glutamate receptor antagonist.
Biological Activity
Active isomer of (RS)-MCPG ((RS)-a-Methyl-4-carboxyphenylglycine ). Non-selective group I/group II metabotropic glutamate receptor antagonist. Also available as part of the Group I mGlu Receptor Tocriset™ , Group II mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .
Biochem/physiol Actions
(+)-α-Methyl-4-carboxyphenylglycine, also known as MCPG, is a competitive metabotropic glutamate receptor antagonist.
Storage
Room temperature
Properties of (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
| Boiling point: | 425.3±40.0 °C(Predicted) |
| Density | 1.390±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | 0.1 M NaOH: 15 mg/mL |
| form | solid |
| pka | 1.76±0.10(Predicted) |
| color | White to off-white |
| optical activity | [α]20/D +89.54°, c = 0.33 in 6 M HCl(lit.) |
Safety information for (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
Computed Descriptors for (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
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