(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE

Synonym(s):(+)-MCPG;S(+)-α-Amino-4-carboxy-α-methyl-benzeneacetic acid

CAS NO.：150145-89-4
Empirical Formula: C10H11NO4
Molecular Weight: 209.2
MDL number: MFCD00216858
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-24 08:04:07

(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE Structural

What is (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE?

Chemical properties

white to off-white solid

The Uses of (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE

Active enantiomer of (±)-MCPG

What are the applications of Application

(S)-MCPG is a non-selective group I/II mGluR antagonist

Definition

ChEBI: (S)-alpha-methyl-4-carboxyphenylglycine is a non-proteinogenic alpha-amino acid that is alanine in which the alpha-hydrogen is replaced by a 4-carboxyphenyl group (the S-enantiomer). It is a non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. It has a role as a metabotropic glutamate receptor antagonist.

Biological Activity

Active isomer of (RS)-MCPG ((RS)-a-Methyl-4-carboxyphenylglycine ). Non-selective group I/group II metabotropic glutamate receptor antagonist. Also available as part of the Group I mGlu Receptor Tocriset™ , Group II mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .

Biochem/physiol Actions

(+)-α-Methyl-4-carboxyphenylglycine, also known as MCPG, is a competitive metabotropic glutamate receptor antagonist.

Storage

Room temperature

Properties of (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE

Boiling point:	425.3±40.0 °C(Predicted)
Density	1.390±0.06 g/cm3(Predicted)
storage temp.	Store at RT
solubility	0.1 M NaOH: 15 mg/mL
form	solid
pka	1.76±0.10(Predicted)
color	White to off-white
optical activity	[α]20/D +89.54°, c = 0.33 in 6 M HCl(lit.)