(S)-3,5-DIHYDROXYPHENYLGLYCINE

Synonym(s):S-DHPG

CAS NO.：162870-29-3
Empirical Formula: C8H9NO4
Molecular Weight: 183.16
MDL number: MFCD00673763
EINECS: 2017-001-1
SAFETY DATA SHEET (SDS)
Update Date: 2025-04-28 21:36:36

(S)-3,5-DIHYDROXYPHENYLGLYCINE Structural

What is (S)-3,5-DIHYDROXYPHENYLGLYCINE?

The Uses of (S)-3,5-DIHYDROXYPHENYLGLYCINE

(S)-3,5-Dihydroxyphenylglycine hydrate has been used:

as mGluR1/5?agonist for metabotropic glutamate receptor 1 (mGluR1/5) activation in synaptoneurosomal preparations
in ACSF for DHPG stimulation
to inject into basolateral amygdala to study its effect on memory expression

The Uses of (S)-3,5-DIHYDROXYPHENYLGLYCINE

(S)-3,5-Dihydroxylphenylglycine is a potent agonist of group I metabotropic glutamate receptors mGluR1 and mGluR5. (S)-3,5-Dihydroxylphenylglycine have been utilized for the treatment of neuronal injury and cognitive enhancement.

What are the applications of Application

(S)-3,5-DHPG is a selective agonist of group I mGluR

Definition

ChEBI: (S)-3,5-dihydroxyphenylglycine is a glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups. It is a member of resorcinols and a non-proteinogenic L-alpha-amino acid. It is functionally related to a L-alpha-phenylglycine. It is a tautomer of a (S)-3,5-dihydroxyphenylglycine zwitterion.

Biological Activity

Selective group I mGlu receptor agonist. Also available as part of the Group I mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .

Biochem/physiol Actions

(S)-3,5-Dihydroxyphenylglycine hydrate is a group I metabotropic glutamate receptor agonist.

Storage

-20°C (desiccate). Protect from light.

Properties of (S)-3,5-DIHYDROXYPHENYLGLYCINE

Melting point:	>207°C (dec.)
Boiling point:	448.8±33.0 °C(Predicted)
Density	1.550±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	Aqueous Base (Very Slightly, Sonicated), Methanol (Slightly), Water (Slightly, H
form	solid
pka	1.77±0.10(Predicted)
color	white
Water Solubility	Soluble to 50 mM in water
Stability:	Hygroscopic

Safety information for (S)-3,5-DIHYDROXYPHENYLGLYCINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.