(S)-(-)-3-Benzyloxy-1,2-propanediol
Synonym(s):(S)-Glycerol 1-benzyl ether;1-Benzyl-sn-glycerol
- CAS NO.：17325-85-8
- Empirical Formula: C10H14O3
- Molecular Weight: 182.22
- MDL number: MFCD00077914
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:52:28
What is (S)-(-)-3-Benzyloxy-1,2-propanediol?
Chemical properties
white to slightly yellow crystalline low melting
The Uses of (S)-(-)-3-Benzyloxy-1,2-propanediol
(S)-(-)-3-Benzyloxy-1,2-propanediol is a useful building block. It is used in the preparation of the nucleotide analog (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cystosine with antiviral activities. It is also used to synthesize cationic cardiolipin analogs with drug delivery systems such as transfection reagents.
Purification Methods
Purify the diol by repeated fractional distillation. [Baer et al. J Biol Chem 230 447 1958, Gigg & Gigg J Chem Soc C 1865 1967, Beilstein 6 IV 2247.]
Properties of (S)-(-)-3-Benzyloxy-1,2-propanediol
| Melting point: | 24-26 °C(lit.) |
| Boiling point: | 261 °C(lit.) |
| alpha | -5.5o (C=20% IN CHLOROFORM) |
| Density | 1.0966 (rough estimate) |
| refractive index | -5.5 ° (C=20, CHCl3) |
| Flash point: | >230 °F |
| storage temp. | Sealed in dry,2-8°C |
| form | powder to lump to clear liquid |
| pka | 13.65±0.20(Predicted) |
| color | White or Colorless to Light yellow |
| optical activity | [α]20/D 5.5±0.5°, c = 20% in chloroform |
| BRN | 2415534 |
| CAS DataBase Reference | 17325-85-8(CAS DataBase Reference) |
Safety information for (S)-(-)-3-Benzyloxy-1,2-propanediol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (S)-(-)-3-Benzyloxy-1,2-propanediol
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