(S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt)

Synonym(s):S1P1 Control Molecule

CAS NO.：909725-64-0
Empirical Formula: C18H28F3N2O6P
Molecular Weight: 456.4
SAFETY DATA SHEET (SDS)
Update Date: 2025-04-17 18:22:24

(S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt) Structural

What is (S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt)?

Description

W140 is the inactive enantiomer of the sphingosine-1-phosphate receptor 1 (S1P₁) antagonist W146 .¹ It only weakly binds to S1P₁ (K_i = 4.6 μM for the human receptor). W140 has been used as a negative control in vitro and in vivo in the study of S1P₁ signaling.^1,2

References

1. Sanna, M.G., Wang, S.K., Gonzalez-Cabrera, P.J., et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P₁ antagonist in vivo Nat. Chem. Biol. 2(8),434-441(2006).
2. Li, C., Chi, X.X., Xie, W., et al. Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor J. Neurophysiol. 108(5),1473-1483(2012).

Properties of (S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt)

storage temp.	Store at -20°C
solubility	Ethanol: 0.15 mg/ml
form	A crystalline solid

Safety information for (S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt)

Computed Descriptors for (S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt)

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