RSC 133

Synonym(s):3-[[(2E)-3-(1H-Indol-3-yl)-1-oxo-2-propen-1-yl]amino]-benzamide;Reprogramming stimulating compound 133;RSC 133

CAS NO.：1418131-46-0
Empirical Formula: C18H15N3O2
Molecular Weight: 305.33
Update Date: 2026-05-28 05:15:44

What is RSC 133?

Description

RSC-133 is an indole compound that promotes the reprogramming of human somatic cells to pluripotent stem cells. Specifically, when used at 10 μM with four standard reprogramming factors, it increases the number of human foreskin fibroblasts that express the stem cell marker alkaline phosphatase. RSC-133 induces pluripotency by both down-regulating inducers of cellular senescence and inhibiting DNA methyltransferase and histone deacetylase activities.

The Uses of RSC 133

RSC 133 is a potent chemical booster for human somatic cell reprogramming. RSC 133 facilitates the maintenance of pluripotent human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs).

Properties of RSC 133

Boiling point:	653.7±55.0 °C(Predicted)
Density	1.372±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: soluble20mg/mL, clear
pka	13.22±0.70(Predicted)
form	powder
color	white to light brown

Safety information for RSC 133

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment.

Computed Descriptors for RSC 133

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