(RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid
- CAS NO.：909400-43-7
- Empirical Formula: C6H7ClN2O4
- Molecular Weight: 206.58
- MDL number: MFCD04113776
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:52:56
What is (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid?
The Uses of (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor), a heterotetrameric transmembrane receptor, is found in various areas of the brain and mediates fast synaptic transmission in the central nervous system (1). Cl-HIBO (chloro-homoibotenic acid) is a subtype selective AMPA receptor agonist (2).
What are the applications of Application
Cl-HIBO is Chloro-homoibotenic acid, a highly desensitising AMPA receptor agonist. Subtype selective for GluR1 and GluR2 subunit-containing receptors
Biological Activity
Subtype-selective and strongly desensitising AMPA receptor agonist; selective for GluR1 and GluR2 subunit-containing receptors (EC 50 values are 4.7, 1.7, 2700 and 1300 μ M for rat recombinant homomeric GluR1, 2, 3 and 4 receptors respectively).
Properties of (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid
| Density | 1.66±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| pka | 2.26±0.10(Predicted) |
| form | Powder |
| Water Solubility | Soluble to 20 mM in water |
Safety information for (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid
Computed Descriptors for (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid
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