RS-102895 hydrochloride
- CAS NO.：1173022-16-6
- Empirical Formula: C21H22ClF3N2O2
- Molecular Weight: 426.86
- MDL number: MFCD08703093
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-16 07:06:08
What is RS-102895 hydrochloride?
Description
The chemokine CCL2, also known as monocyte chemotactic protein-1 (MCP-1), stimulates leukocyte chemotaxis to sites of inflammation via signaling through the MCP-1 receptor, CCR2. RS 102895 is a spiropiperidine compound that acts as a CCR2 antagonist (IC50 = 0.36 μM). It inhibits the related CCR1 receptor with an IC50 value of 17.8 μM and inhibits adrenergic α1a, α1d, and 5HT1A receptors with IC50 values of 0.13, 0.32, and 47 μM, respectively. RS 102895 prevents chemotaxis of THP-1 cells (IC50 = 1.7 μM) when MCP-1 is presented as a chemoattractant.
The Uses of RS-102895 hydrochloride
RS 102895 Hydrochloride is used as a leukocyte infiltrate marker for rosacea diagnosis.
Storage
Desiccate at RT
Properties of RS-102895 hydrochloride
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMF: 25 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 2 mg/ml |
| form | Powder |
| color | White to off-white |
Safety information for RS-102895 hydrochloride
Computed Descriptors for RS-102895 hydrochloride
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