RS 102895
Synonym(s):1′-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4′-peperidin]-2(1H)-one
- CAS NO.：300815-41-2
- Empirical Formula: C21H21F3N2O2
- Molecular Weight: 390.4
- MDL number: MFCD05865241
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-22 18:57:36
What is RS 102895?
The Uses of RS 102895
RS 102895 is a CCR2-selective chemokine receptor inhibitor.
What are the applications of Application
RS 102895 Hydrochloride is a CCR2-selective chemokine receptor antagonist
Biological Activity
CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors.
Properties of RS 102895
| Boiling point: | 446.1±45.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Desiccate at RT |
| solubility | DMSO: 18 mg/mL, clear, colorless |
| form | powder |
| pka | 13.46±0.20(Predicted) |
| color | white |
Safety information for RS 102895
Computed Descriptors for RS 102895
New Products
2-Ethoxyphenol Methyl 2-methoxy-5-sulfamoylbenzoate 3,6-Dichloropyridazine Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 3,6-Dichloro-4-Isopropylpyridazine 2-[(2-Ethoxyphenoxy)methyl]oxirane 4-Morpholinoaniline 2-Chloromethyl-6-methyl-pyridine 1-Indanone tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 2-Pyridinecarboxaldehdye 6-Methyl-2-pyridinemethanol 4-Bromo-2-fluoro-N-methylbenzamide 3-Azetidinecarboxylic acid N-(2-(4-((4-Fluorobenzyl)carbamoyl)-5-hydroxy-6-methoxypyrimidin-2-yl)propan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide (R)-4-Boc-morpholine-3-carboxylic acid (Required high chiral purity NLT:99.5%) Tetrahydro-3-(2-methyl-2- nitropropyl)-2H-pyran-2-one 3-Bromo-2-fluorobenzonitrile Desoximetasone Boron Triiodide Nicotinic acid RAPAMYCIN Pentachlorobenzonitrile BudesonideRelated products of tetrahydrofuran
![SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE](https://img.chemicalbook.in/CAS/GIF/84060-09-3.gif)
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