RS 102895
Synonym(s):1′-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4′-peperidin]-2(1H)-one
- CAS NO.：300815-41-2
- Empirical Formula: C21H21F3N2O2
- Molecular Weight: 390.4
- MDL number: MFCD05865241
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-16 07:06:08
What is RS 102895?
The Uses of RS 102895
RS 102895 is a CCR2-selective chemokine receptor inhibitor.
What are the applications of Application
RS 102895 Hydrochloride is a CCR2-selective chemokine receptor antagonist
Biological Activity
CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors.
Properties of RS 102895
| Boiling point: | 446.1±45.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Desiccate at RT |
| solubility | DMSO: 18 mg/mL, clear, colorless |
| form | powder |
| pka | 13.46±0.20(Predicted) |
| color | white |
Safety information for RS 102895
Computed Descriptors for RS 102895
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![SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE](https://img.chemicalbook.in/CAS/GIF/84060-09-3.gif)
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