RKS-262
- CAS NO.：1041469-97-9
- Empirical Formula: C15H14BrClN2O4S
- Molecular Weight: 433.71
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-20 17:00:22
What is RKS-262?
Description
RKS262 is a specific cycliCDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cell-line assay RKS262 exhibited significant cytotoxicity in ovarian cancer cells and a variety of other cell lines exceeding effects of commercial drugs such as cisplatin, 5-FU, cyclophosphamide or sapacitabine. Various leukemia cell-lines were most sensitive (GI(50):?~?10 nM) while several non-small cell lung cancer cell lines and few cell lines from other tissues were relatively resistant (GI(50)?>?1?μM) to RKS262 treatment.
Properties of RKS-262
| Boiling point: | 616.8±65.0 °C(Predicted) |
| Density | 1.74±0.1 g/cm3(Predicted) |
| pka | -0.47±0.40(Predicted) |
Safety information for RKS-262
Computed Descriptors for RKS-262
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