RIPK1-IN-7
- CAS NO.：2300982-44-7
- Empirical Formula: C25H22F3N5O2
- Molecular Weight: 481.47
- Update Date: 2026-04-22 18:57:36
What is RIPK1-IN-7?
Biological Activity
RIPK1-IN-7 is a receptor-interacting protein kinase 1 (RIPK1) inhibitor with a Kd of 4 nM and an IC50 of 11 nM. RIPK1-IN-7 has good anti-metastatic activity in an experimental B16 melanoma lung metastasis model.
in vitro
RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC 50 of 2nM.
It displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC 50 s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively.
Properties of RIPK1-IN-7
| Boiling point: | 724.8±60.0 °C(Predicted) |
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 62.5 mg/mL (129.81 mM); Water: < 0.1 mg/mL (insoluble) |
| form | Solid |
| pka | 5.76±0.30(Predicted) |
| color | Light yellow to yellow |
Safety information for RIPK1-IN-7
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for RIPK1-IN-7
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