RG7440-NH2
- CAS NO.：1001382-14-4
- Empirical Formula: C21H26ClN5O2
- Molecular Weight: 415.92
- MDL number: MFCD34470246
- Update Date: 2026-09-12 18:53:41
What is RG7440-NH2?
Biological Activity
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References
[1]. You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.
Properties of RG7440-NH2
| Boiling point: | 660.3±55.0 °C(Predicted) |
| Density | 1.341±0.06 g/cm3(Predicted) |
| solubility | DMSO : 210 mg/mL (504.90 mM; Need ultrasonic) |
| pka | 13.11±0.40(Predicted) |
| form | Solid |
| color | Off-white to light yellow |
Safety information for RG7440-NH2
Computed Descriptors for RG7440-NH2
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