Reversan

Synonym(s):CBLC4H10;N-[3-(4-Morpholinyl)propyl]-5,7-diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxamide

CAS NO.：313397-13-6
Empirical Formula: C26H27N5O2
Molecular Weight: 441.52
MDL number: MFCD01528184
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-21 10:31:43

What is Reversan?

The Uses of Reversan

Reversan represents a new class of nontoxic MRP1 inhibitor, which may be clinically useful for the treatment of neuroblastoma.

What are the applications of Application

Reversan is selective inhibitor of Mdr-1 that increases efficacy of etoposide in murine models of neuroblastoma

Biological Activity

Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin , vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo . Displays at activity on MRP2, MRP3, MRP5 and MRP5 transporters.

Storage

Store at -20°C

Properties of Reversan

Melting point:	176-180°C
Density	1.26±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	DMSO: ≥8mg/mL at ~60°C
form	powder
pka	11.33±0.46(Predicted)
color	faint yellow to yellow

Safety information for Reversan

Computed Descriptors for Reversan

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