Retronecanol

Empirical Formula: CBHISON
Molecular Weight: 0
Update Date: 2026-09-12 18:55:54

What is Retronecanol?

Description

This simple pyrrolizidine compound is formed during the hydrolysis of several of the hepatotoxic alkaloids, but also occurs naturally in Crotalaria spectabilis and Senecio longilobus. It yields colourless crystals from petroleum ether and has [α]_D - 105° (CHCl3) or [α]²⁸_D - 91.1° (EtOH). It forms a hydrochloride as white prisms from MeOH-Et20, m.p. 210°C (dec.); a methiodide, m.p. 193°C (dec.); [α]²⁷_D - 52.8° (MeOH) and a picrate, m.p. 210°C. The picrolonate is also crystalline, yellow prisms from EtOH, m.p. 184-5°C. The monoacetate furnishes a picrate, m.p. 176° C and a methiodide, m.p. 207 _8° C.

References

Manske., Can. J. Res., 5, 651 (1931)
Barger et al., J. Chern. Soc., 11 (1935)
Adams, Roger.,J. Arner. Chern. Soc., 61,2815 (1939)
Konovalova, Orekhov., Bull. Soc. Chirn. Fr., 4, 1285 (1937)
Adams, Govindachari.,J. Arner. Chern. Soc., 71, 1180 (1949)

Properties of Retronecanol

Melting point:

95-6°C; B.p. 140°C/30 mm

Safety information for Retronecanol

Computed Descriptors for Retronecanol

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