REC IL-1RA (HUMAN)
Synonym(s):ICIL-1RA;IL-1RN;IRAP
- Molecular Weight: 0
- MDL number: MFCD00241901
- Update Date: 2025-01-27 09:38:02
What is REC IL-1RA (HUMAN)?
General Description
The gene IL-1RA (interleukin-1 receptor antagonist) is mapped to human chromosome 2q. It belongs to the IL-1 (interleukin 1) family of proteins. The encoded protein has a TIR (Toll/IL-1 receptor) domain. IL-1RA is produced by corneal epithelial cells, monocytes, neutrophils, macrophages and fibroblasts. It is a naturally occurring inflammatory inhibitor protein. Recombinant human IL-1RA is a 17.2kDa protein consisting of 153 amino acid residues.
Biochem/physiol Actions
Interleukin-1 receptor antagonist (IL-1RA) inhibits the activity of IL-1α (interleukin 1 α) and IL-1β (interleukin 1 β) by competitively blocking binding to their type I and type II receptors. Therapeutically, IL-1RA may help in the treatment of sepsis, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Low production of IL-1RA is observed in HIV-1 (human immunodeficiency virus 1)-infected dendritic cells.
Properties of REC IL-1RA (HUMAN)
| storage temp. | -15°C |
Safety information for REC IL-1RA (HUMAN)
Computed Descriptors for REC IL-1RA (HUMAN)
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