RAS INHIBITORY PEPTIDE
- CAS NO.：159088-48-9
- Empirical Formula: C53H91N19O11
- Molecular Weight: 1170.41
- MDL number: MFCD00237248
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-06-18 16:39:23
What is RAS INHIBITORY PEPTIDE?
Description
Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.
What are the applications of Application
Sos SH3 domain inhibitor is blocks Sos/GRB2 interaction, preventing Ras activation
Properties of RAS INHIBITORY PEPTIDE
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: Miscible; PBS (pH 7.2): 10 mg/ml |
| form | A crystalline solid |
| pka | 3.31±0.10(Predicted) |
Safety information for RAS INHIBITORY PEPTIDE
Computed Descriptors for RAS INHIBITORY PEPTIDE
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